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1011 In the last ten years, prolonged publicity to anticholinergic drugs has long been associated with long term cognitive decrease or dementia incidence amongst community residing cohorts and nursing home citizens.121314151617 On the other hand, these studies are actually confined in their capability to find out In case the increased risk is precise towards the anticholinergic action by itself, and whether the Affiliation is owing for the medicine or even the underlying circumstances for which they had been prescribed. In particular, late existence despair is regarded as an early symptom of dementia,1819 While studies of regardless of whether midlife depression is really a chance element for later everyday living dementia have had mixed findings.2021
We experienced 3 aims. First of all, to estimate the Affiliation amongst Persistent anticholinergic drug use and long term dementia incidence when controlling for likely confounders. Next, to explore whether or not any noticed effect was precise to a specific drug course. Thirdly, to test how the Affiliation varied While using the time and energy to dementia incidence and level of exposure inside of Every single course.
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